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An injectable formulation of a neurotoxin derived through the fermentation of the hall strain of Clostridium botulinum type a with neuromuscular transmission inhibitory and analgesic activities. Upon injection into the affected muscle, the heavy chain portion of onabotulinumtoxinA binds to the cell membrane of the motor nerve and is internalized via endocytosis. Upon entry, the light chain portion of the toxin is activated and cleaves the protein snap-25, thereby preventing the fusion of acetylcholine (ACh)-containing synaptic vesicles with the cell membrane and, so, the release of ACh into the neuromuscular junction; subsequent binding goji of ach to motor. In addition to ach, onabotulinumtoxinA may inhibit the release of neuropeptides, such as substance p zuurstoftherapie and glutamate, which may contribute to its analgesic activity.

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